Dapoxetine
Dapoxetine is a medication used to treat premature ejaculation in men. It is known by the trade name Priligy.
Here are the characteristics of dapoxetine
Mechanism of action
- Dapoxetine belongs to a class of medications called selective serotonin reuptake inhibitors (SSRIs).
- It works by slowing the reuptake of the neurotransmitter serotonin, which increases the availability of serotonin in the brain.
- Increased serotonin levels have an effect on ejaculation control and allow for a prolonged time to ejaculation.
Indications
- Dapoxetine is primarily used to treat premature ejaculation in men.
- It is indicated for men aged 18 to 64 years who have problems with rapid ejaculation.
Onset of action
- Dapoxetine has a rapid onset of action that usually occurs about 1 to 2 hours after taking the medication.
Duration of action
- The effects of dapoxetine usually last 4 to 24 hours, which depends on the dose and the individual patient’s response.
Dosage
- The usual dosage for dapoxetine is 30 mg to 60 mg, taken as needed.
- The recommended starting dose is usually 30 mg, and the physician may adjust the dose according to individual response.
Side effects
- Common side effects of dapoxetine include dizziness, headache, nausea, drowsiness, fatigue, and dry mouth.
- Rarely, hot flashes, increased nervousness, behavioral changes, or changes in sexual function may occur.
Contraindications
- Dapoxetine should not be used in patients with severe hepatic or renal dysfunction, severe heart problems, epilepsy, bipolar disorder, or taking MAO (monoamine oxidase) inhibitors.
- It is important to avoid combining dapoxetine with alcohol as this may increase the risk of side effects.
Avanafil
Avanafil is a drug used to treat erectile dysfunction in men, which is known by the brand name Stendra. It belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors.
Here are the characteristics of avanafil
Mechanism of action
- Avanafil works by increasing blood flow to the penis during sexual stimulation. It blocks the enzyme phosphodiesterase type 5 (PDE5), which allows the smooth muscles of the blood vessels in the penis to relax and increase blood flow, which in turn helps to achieve and maintain an erection.
Rapid onset of action
- Avanafil has a reputation as a fast-acting erectile dysfunction drug. Its effects usually appear within 15 to 30 minutes after taking it, which is faster than other drugs for similar disorders.
Duration of action
- the effects of avanafil usually last up to 4 to 6 hours. During this time, a man can achieve and maintain an erection long enough for satisfactory sexual intercourse.
Dosage
- The usual initial recommended dose of avanafil is 100 mg, which may be increased to 200 mg or decreased to 50 mg according to individual response and needs.
Side effects
- Common side effects of avanafil include headache, facial flushing, digestive problems (e.g. nausea, diarrhea), dizziness, and increased blood pressure. Rarely, hearing loss or changes in vision may occur.
Contraindications
- Avanafil is contraindicated in patients taking nitrates or other nitrate-containing drugs. It should also not be used in men with serious heart problems, recent heart attack or stroke.
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