Ajanta Tadalis-SX 4 tabs (20 mg/tab)

Tadalafil – Cialis

Tadalafil is a leading medication categorized as a phosphodiesterase type 5 (PDE5) inhibitor, primarily promoted under the brand name Cialis for erectile dysfunction and Adcirca for pulmonary arterial hypertension.

Key Characteristics of Tadalafil

Mechanism of Action

• Tadalafil inhibits the enzyme phosphodiesterase type 5 (PDE5), which typically degrades cyclic guanosine monophosphate (cGMP).
• Upon sexual arousal, nitric oxide (NO) release enhances cGMP levels within the penis.
• This leads to the relaxation of blood vessel smooth muscles, boosting blood flow for a successful and sustained erection.

Indications

• Tadalafil is primarily indicated for treating erectile dysfunction in men.
• It also addresses benign prostatic hyperplasia (BPH) and aids in treating pulmonary arterial hypertension as Adcirca.

Onset of Action

• Tadalafil typically acts quickly, with effects starting within 30 minutes to 1 hour post-administration.

Duration of Action

• The effects of tadalafil may persist for up to 36 hours, earning it the nickname “weekend pill.”
• This offers men the chance to maintain an erection throughout the duration if sexually stimulated.

Dosage

• For erectile dysfunction relief, the standard dose ranges from 10 mg to 20 mg, taken approximately 30 minutes before sexual activity.
• For BPH treatment, a daily dose of 5 mg is generally recommended.

Side Effects

• Common side effects may include headache, facial flushing, indigestion (nausea, diarrhea), dizziness, muscle aches, and back pain.
• In rare cases, serious side effects such as unexpected vision or hearing loss may occur.

Contraindications

• Avoid combining tadalafil with nitrates (e.g., nitroglycerin) due to the risk of substantial blood pressure drops.
• It is not advised for individuals with severe heart conditions or those who have recently suffered a myocardial infarction or stroke.