Pfizer Genotropin 1 vial (1x 36 IU)

HGH – human growth hormone

Human growth hormone, or HGH, is a naturally produced hormone by the anterior pituitary gland, crucial for growth and development. Secretion of GH begins at birth, peaking during late adolescence. As individuals reach their twenties, growth hormone levels gradually decline. For over four decades, prescribed growth hormone has been effective in treating certain medical conditions. Recently, a surge in its recreational use has emerged, with middle-aged and elderly individuals believing it counters aging, teens seeking body enhancement, and athletes looking for performance boosts. Among athletes, Growth hormone is one of the top three most abused substances.

What is Human Growth Hormone?

HGH activates cell production and metabolic functions necessary for human growth. Secreted by the anterior pituitary at the skull’s base, GH regulates growth and development alongside other hormones. Its highest levels occur at puberty, with significant declines beginning around age 40. Growth hormone can be found in health food stores and wellness spas, often marketed under names like Genotropin®, Humatrope®, and others.

Pharmacology

The majority of available GH is produced via recombinant DNA technology. The synthetic forms, somatropin and somatrem, mimic natural growth hormone, as they bind to GH receptors, instigating numerous cellular processes. Growth hormone influences metabolism, fluid balance, and muscle mass, with levels increasing in response to stress, sleep, and exercise.

Conditions Affecting GH Levels

Medical conditions can arise from abnormal GH levels. Excessive human growth hormone can lead to acromegaly, a disorder marked by extreme body enlargement and serious health issues, or pituitary gigantism, characterized by excessive height. Conversely, GH deficiency can result in significant health challenges and stunted growth.

FDA Approved Uses of Growth Hormone

The FDA has sanctioned several injectable HGH preparations, available only via prescription. Initially approved in 1985 for short stature due to GH deficiency, further approvals emerged for conditions such as Prader-Willi syndrome and chronic renal insufficiency. Moreover, it is prescribed for adults facing AIDS wasting syndrome. Evidence supports that GH injections can yield results like:

• enhanced muscle mass and bone density
• reduced body fat
• improved cognitive function
• better exercise performance
• increased cardiovascular stress tolerance

Dosage

GH is exclusively administered through injection—subcutaneously or intramuscularly. Effects commence swiftly upon absorption, but suitable dosing remains somewhat unclear. While current research advocates for dosage based on IGF levels, many healthcare providers rely on body weight, with typical adult doses ranging from 0.01 to 0.1 mg/kg. Available forms include powder (requiring solubilization) or liquid.

Possible Side Effects of Growth Hormone

GH may provoke various side effects, commonly including:

• widespread edema
• carpal tunnel syndrome
• joint and muscle discomfort
• neuropathies (e.g., numbness)
• elevated blood glucose

Prescription Requirement for Growth Hormone

Prescriptions for GH are mandated for FDA-approved purposes. Nonetheless, off-label uses—like performance enhancement and anti-aging—are prevalent. Despite claims of miraculous benefits, the FDA has not endorsed these due to potential risks outweighing rewards. Patients should cautiously consider side effects prior to engaging in treatment.

Risks Associated with Growth Hormone

The possibility of overdose with GH remains, potentially leading to dire health issues such as acromegaly and heightened risks for certain cancers. Lesser side effects may involve fluid retention, type 2 diabetes, and joint discomfort. Individuals contemplating GH therapy must assess the balance of risks versus benefits thoroughly.

Off-Label Uses

BodybuildingThe illicit use of HGH is predominantly seen in the bodybuilding community. Despite being illegal, it is readily available. Bodybuilders often mix it with various drugs, complicating the evaluation of its effectiveness. Notably, GH has gained notoriety for being difficult to detect, resulting in many athletes’ reliance on it. Costs for those using HGH can be substantial, ranging from $500 to $2000 per month, with risks of counterfeit products.

Anti-Aging Applications

Another common off-label application of HGH revolves around the desire to maintain youthfulness. Despite rampant speculation, it lacks FDA approval for anti-aging. No credible findings support its efficacy in reversing skin aging or improving skin quality, despite the surge in related products leading to a $70 million industry.

Accessibility

Unfortunately, the majority acquire HGH through illegitimate channels, including pharmacy theft, unethical prescriptions, or smuggling. A considerable number of internet pharmacies exist, often licensing prescriptions without proper consultations. Many opt for illegal avenues to obtain HGH, with various marketed alternatives, like sprays and gels, proving ineffective as they offer minimal absorption.

Challenges in Detection

Identifying synthetic HGH in the body presents difficulties. Current testing methods can only detect it within 48 hours post-injection, providing an advantage to athletes who are mindful of testing protocols.

Sermorelin

Sermorelin, a newer alternative, is a counterfeit version of Geref produced in China. As a biological analog of growth hormone-releasing hormone, it boosts growth hormone production but is also undetectable post-administration. Though taking 3-4 weeks for notable effects, its safety profile is better than GH, but it offers limited benefits for those with inherent GH deficiency. Costs for Sermorelin range from $300 to $1000 monthly.

Regulatory Status

The rampant abuse of GH has prompted federal regulations restricting its sale and distribution. The Anabolic Steroids Control Act labels possession or distribution as a crime, with severe penalties. In March 2007, legislation introduced in the U.S. Senate proposed classifying it as a schedule III controlled substance. GH is also recognized under the World Anti-Doping Agency and the International Olympic Committee as a performance-enhancing substance, barring its use in competitive sports.