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Sildenafil

Sildenafil, commonly known as Viagra, is a member of the PDE5 inhibitors class of medications.

Discover the key characteristics of Sildenafil:

Mechanism of Action

• Sildenafil effectively inhibits the enzyme PDE5, preventing the breakdown of cyclic guanosine monophosphate (cGMP).
• This process enhances the effects of nitric oxide (NO) during sexual stimulation, leading to increased blood flow and subsequent relaxation of the penile smooth muscles.

Indications

• Primarily prescribed for treating erectile dysfunction in men.
• Also indicated for managing arterial hypertension under the brand name Revatio.

Onset of Action

• The onset is rapid, typically within 30 minutes, although some might experience effects up to an hour later.

Duration of Action

• Effects generally persist between 4 to 5 hours, facilitating erection achievement and maintenance.

Dosage

• The standard starting dose is 50 mg, adjustably tailored based on individual responses.
• Recommended to be consumed approximately 30 minutes to 1 hour prior to anticipated sexual engagement.

Side Effects

• Common side effects may encompass headaches, facial flushing, gastrointestinal issues, visual disturbances, elevated blood pressure, and in rare cases, hearing alterations.

Contraindications

• Do not administer alongside nitrates (e.g., nitroglycerin) due to the risk of significant blood pressure drops.
• Contraindicated for individuals with severe cardiovascular conditions, recent myocardial infarctions, or strokes.