Pegylated Mechano Growth Factor (PEG-MGF)
is a type of IGF gene that is also known as a peptide used during recovery after heavy exercise. It works by repairing injured muscle tissues in an enhanced way compared to the known IGF-1; a peptide that is used for children’s growth and anabolic functions in adults.
Both PEG-MGF and IGF-1 are polypeptide hormones and are different from myoblasts where embryonic cells develop to muscle fibres. PEG-MGF can cause myoblast division as well as the maturation of the muscle fibres. These functions are necessary for promoting the growth of muscles in adults.
When MGF was first developed, one challenge that its users had was that it did not stay for long in their body. Since PEG MGF is water-based, it will last for a few minutes in your body. That is the reason why the researchers opted to pegylate the MGF.
This meant that MGF was now combined with a polyethylene glycol molecule. This has helped the breakdown to be fast and to flow through the bloodstream efficiently.
Solubility & Storage
It is highly recommended to dilute the Lyophilised PEG-MGF in sterilised water, and you can further dilute it in another aqueous solution. Although Lyophilised PEG-MGF is stable at room temperature within 3-4 weeks, it should be desiccated and stored below -18°C. When reconstituted, PEG-MGF must be stored at 4°C and away from direct light for 10-14 days. Storage for future use should be done below -18°C. However, you should avoid repeated freeze-thaw cycles.
Results & Benefits
Since the MGF injection is short-lived, it is essential to use an additional substance known as Polyethylene Glycol (PEG) to increase the protection of the MGF molecules and to help it last in the body for a longer time.
PEG-MGF leads to the constant production of satellite cells in the muscle fibres which initiate the process of hypertrophy in adult muscles. This process occurs when the skeletal muscle increases in size due to the growth of the size of its cells. Satellite cells also arouse muscle regeneration by producing a spare population of cells that are ready to multiply whenever you have a muscular injury.
The PEG-MGF helps in the retention of nitrogen, which enables the measurement of the amount of protein that is available in one’s body. Protein is an essential nutrient for body tissues and acts as the raw material used for building muscles.
PEG-MGF increases the synthesis of muscle protein that promotes the growth of muscles. When you exercise, your muscles experience small micro-tears resulting in increased blood flow to the area involved. This initiates a reaction on this protein to repair the injured muscle. It is this process that enables the muscle to become larger and stronger.
Since the Pegylated Mechano Growth Factor has not been exhaustively studied, there are not many side effects that have been confirmed.
- Suggested frequency of use: two times a week.
- Where to inject: injected into the body fat around the stomach area.
- Suggested injection dosage per time: 200-400 MCG.